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Therefore, following the approval of Exenatide, development of GLP-1 drugs mainly focused on two directions: developing long-acting GLP-1RAs and oral GLP-1RAs (Figure 3)

Severe malabsorption, significant weight loss already occurring from disease activity, or concurrent use of certain immunosuppressants can shift the benefit-risk balance

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These medical-grade formulations bypass the digestive system and are rapidly absorbed through the lungs, helping to reduce inflammation, enhance oxygen exchange, and strengthen immune defense