The problem is that the tablets that doctors can currently prescribe in the UK are nowhere near 1mg in strength, I believe they are 50mcg and the suggested dosage is 50-150 mcg taken between meals so for 150mcg you would take 3 tablets
Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions
The American Academy of Family Physicians confirms that oral doses of 1,000 to 2,000 mcg daily can correct both anemia and neurologic symptoms in most deficient patients
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