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Research has examined Semaglutides effects on dopaminergic reward circuit biology , characterising attenuation of substance reward responses and addiction-associated behaviours through GLP-1R-mediated dopamine system modulation in the nucleus accumbens and ventral tegmental area , and neuroprotective effects in neurodegenerative models through GLP-1R-mediated neuroinflammation attenuation, microglial activation modulation, and neuroprotective signalling pathway engagement

Huang WC, Tung SL, Chen YL, Chen PM, Chu PY

"The biggest concern is that there's not a lot of data on how safe it is in animals," said McGrath

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Dopamine (DA) is a crucial neurotransmitter