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The reduction in food intake may be related to the activity of GIP, able to cross the blood barrier, on its receptors sited in the arcuate (ARC) nucleus and other hypothalamic centers
138 YeLMuellerOBagwellJBagnatMLiddleRARawlsJF
This is a primary reason why a slow and steady dose titration is the standard protocol.
these take precedence over any general guidance
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