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8.6 Renal Impairment The dosing requirements for SYMLIN are not altered in patients with mild (creatinine clearance [ClCr] 60-89 mL/min), moderate (ClCr 30-59 mL/min) or severe renal impairment (ClCr 15-29 mL/min)

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Reports of semaglutide depression , anxiety, and emotional flatness have circulated in online communities, patient forums, and even media outlets

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Many users report increased energy and reduced fatigue while taking semaglutide