can semaglutide delay period Cause Infertility? Evidence and Guidance Understanding the Impact of Weight

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High-dose semaglutide (7.2mg weekly) represents another near-term development

Interestingly, 27-hydroxycholesterol (27HC), a cholesterol metabolite, can increase cellular lipid uptake and/or biosynthesis, thus increasing intracellular metabolic stress, which can upregulate the expression of GPX4 and suppress ferroptosis, ultimately promoting tumorigenicity and metastasis [153]

Laboratory monitoring should continue for several weeks after discontinuation, particularly hemoglobin A1c and weight measurements, to assess metabolic trajectory and guide subsequent management

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