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FDA approval for a new indication for Wegovy (semaglutide) to reduce the risk of major adverse cardiovascular events, including cardiovascular death, heart attack, and stroke, in adults with cardiovascular disease and obesity or overweight
That modification is the key engineering trick: it makes the molecule more resistant to the enzymes that would normally break GHRH down quickly, giving tesamorelin a longer working window than sermorelin while still acting on the same GHRH receptor
Boland ML, Laker RC, Mather K, et al
Generally, tirzepatide weight loss results have shown a higher percentage of body weight loss on average compared to semaglutide at their respective maximum doses
Mild injection site reactions, transient flushing, and gastrointestinal effects are commonly reported
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