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Challenges in MASH Drug Development Complexity of MASH MASH is a complex condition requiring treatments to address fat accumulation, inflammation, and fibrosis simultaneously
The global burden of obesity and Type 2 diabetes continues to rise
Since the two different pharmacological activities of the peptide antibody fusion molecule cannot be titrated separately, precise adjustment of the potency at GLP-1R was required to achieve effective and safe GLP-1 activity at doses likely able to suppress PCSK9
This issue of scale creates an opening for AI-based companion products that provide supplemental support based on a specialists advice
Zhao X, Wang M, Wen Z, et al
