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Given the complementary roles of PDE1B and PDE10A within striatal dopaminergic circuits, selective inhibition of either enzyme addresses only specific symptom domains of schizophrenia, limiting overall therapeutic efficacy
At PEAK, Contrave is prescribed as part of a clinical treatment program often as a step therapy medication or alongside other approaches in a medication plan
doi: 10.1210/jc.2014-3865 9 DeaconCF
This allows them to focus on broader lifestyle adjustments rather than managing avoidable symptoms
Patients with severe kidney disease or end-stage renal disease may not be appropriate candidates for this therapy, particularly if they have significant fluid retention or are prone to dehydration
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