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Differences: Duration of Action: Short-acting GLP-1RAs (e.g., exenatide twice daily or lixisenatide) act by primarily delaying gastric emptying
Pubblicazione del trial SOUL (NEJM, marzo 2025) la semaglutide orale (Rybelsus) riduce del 14% i MACE in pazienti con diabete tipo 2 e malattia CV/renale
Supports cognition and may offer brain protection.*
These combined mechanisms naturally lead to reduced overall caloric intake, ultimately supporting steady and sustainable weight loss
If Retatrutide is approved in the future, it is possible that: Private prescribing may become available first NHS eligibility could follow later, subject to NICE guidance However, this will depend entirely on the final licence conditions, safety profile and cost effectiveness decisions
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