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Scoring was based on the method described by (Schneider and Przewocki 2005), using a scale from 0 to 1: a score of 0 indicated that all pups had their eyes closed

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The rapid change in the degree of reduction of sensors with significantly less negative E values than E values of roGFP2 and roGFP1 (Table 1) can be further illustrated by the first derivative dReD/dt of the degree of reduction

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