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Vidal and Boletzky 2014)
In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression
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or were fed DOX-supplemented chow (200mg/kg) or chow-alone for 48 hrs
Moreover, enzymes (alcohol dehydrogenase 1, aldehyde dehydrogenase 2, and cytochrome P450 2E1) and regulators (farnesoid X receptor) involved in alcohol metabolism were markedly increased in APP/PS1 mice treated with alcohol compared to WT controls, indicating dysregulated alcohol metabolism
However, specific policies and support mechanisms vary across different NHS trusts and Integrated Care Boards (ICBs)
