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Beyond its glucose-lowering effects, metformin demonstrates additional metabolic benefits by improving insulin sensitivity and ameliorating insulin resistance 5

However, it's important to note that semaglutide is not FDA-approved specifically for the treatment of MASH, and benefits are largely mediated through weight loss

Ozempics once-weekly regimen is well-received by patients due to its simplicity and the relatively fast onset of weight loss effects, especially when paired with healthy lifestyle changes

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