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Despite the presence of L cells in the duodenum, they are not responsible for the GLP-1 release as removing the jejunum-ileum before infusing the duodenal compartment with fat prevents the observed increase of plasma GLP-1 (Roberge et al., 1996)
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Digestive issues like nausea, bloating, or diarrhea are fairly common when beginning weight loss medications for PCOS
Originally developed to help manage blood sugar levels in people with diabetes, it belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists
Summary: Long-term calorie restriction doesnt appear to directly impact IGF-1 levels in humans, although it may make it less active
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