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Suicidal Thinking and Behavior Counsel patients, their caregivers, and families that AEDs, including valproic acid, may increase the risk of suicidal thoughts and behavior and to be alert for the emergence or worsening of symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts, behavior, or thoughts about self-harm

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management remains largely supportive, and investigational therapies have not yet translated into routine clinical practice