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Future Research Needed to Optimize Treatment Strategies The authors acknowledged several limitations of their study, including that trial durations of 48 to 72 weeks are too short to assess whether histologic gains translate into reduced rates of cirrhosis or mortality over the long term
Working with so-called XX mice embryos bred to develop into females they introduced the mutation into a section of DNA known as Enh13, which controls the activity of Sox9
Supporting this, the tracer experiments in mice show that NMN is first converted into either NAM or NR before NAD + synthesis in most tissues 69
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