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PMID 12167058

Crucially, despite this variability, subsequent meta-analyses pooling the data from injectable GLP-1RAs have demonstrated a significant overall reduction in the risk of hospitalisation for HF with GLP-1RAs

Human trials are small, but results have been promising

[5] This rapid breakdown explains why therapeutic GLP-1 receptor agonists have been chemically modified to resist DPP-4 degradation, thereby extending their duration of action and clinical efficacy in managing diabetes and obesity

Cheap and widely available, but poorly absorbed

However, long-term clinical studies (Phase 4) have not confirmed a heightened risk of bleeding after ghutathione