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Having a lack of intrinsic factor (IF) , a substance that binds to B12 so it can be absorbed into the bloodstream (5)
"Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing." Cell and Tissue Research, 2019;377(2):153-159
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Rare hypersensitivity reactions to B12 preparations can occur, which might include systemic symptoms, though joint pain specifically is not typically reported
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