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However, the review emphasized that the majority of studies utilized small rodent models, and efficacy in humans remains to be confirmed through adequately powered clinical trials

Safety and regulation are uncertain, with insufficient clinical data, potential adverse reactions, and unapproved regulatory status

But if your B12 is high without supplementation , it can be a marker for underlying conditions that require medical evaluation, including liver disease, kidney dysfunction, and certain cancers

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After reconstitution, both peptides tend to become quite unstable and thus need to be refrigerated and applied within a certain time frame