This peptide has gained considerable attention in dermatology and aesthetic medicine due to its demonstrated efficacy in wound healing, skin regeneration, hair follicle stimulation, and anti-aging applications
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Given that TMCA can promote the GLP-1 production as a natural FXR antagonist 30 , we speculated that TMCA is a major contributor to the T3 effect on GLP-1 and insulin production and glucose homeostasis
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[50] However, it is important to note that fenfluramine, rimonabant and lorcaserin used very different molecular mechanisms (acting mainly on serotonin 2c receptors [51] in the hypothalamus [52] or CB1 receptors [53] ) from GLP1R, GIPR or GR agonists and likewise do not imply anything on the possible dangers of GLP1R, GIPR or GR agonists