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According to the specific oxidation position, the 12/15-LOX is in charge of catalyzing AA to 12-/15- hydroperoxyeicosatetraenoic acid (12-/15-HpETE) (Ackermann et al., 2017)
It enhances intracellular GSH synthesis and acts as both a direct and indirect antioxidant, scavenging major oxidants such as OH, NO 2 , and thiyl radicals, though less effectively against superoxide and hydrogen peroxide (3)
Treatment usually begins with a low dose, gradually increasing to achieve desired outcomes
In response, enteroendocrine cells upregulate GLP-1 secretion, and GLP-1 receptor activation has been shown to suppress pro-inflammatory cytokines and macrophage infiltration
The results of that WHI study were misinterpreted, and women suffered because of it
Zelniker, T
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