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It is one of the most potent pro-cognitive compounds identified in preclinical research, with reported activity approximately 7 orders of magnitude (10 million times) more potent than BDNF in promoting synaptogenesis in hippocampal cell culture models
Moreover, this system allows to quantify dynamic behaviors of the intestinal barrier as they occur, over time, in high temporal resolution
Much of what is understood about its mechanism is extrapolated from research on natural IGF-1 and growth hormone physiology, rather than dedicated trials on the LR3 analog itself
Rossignol and Frye, 2011
Philp D
It reduces methylationdriven consumption of NAM, increases substrate availability for NAD+ synthesis, and promotes NAD+ biosynthesis to elevate intracellular NAD+ levels
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