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Synergistic activation of mitochondrial metabolism and the glutathione redox couple protects HepG2 hepatocarcinoma cells from palmitoylcarnitine-induced stress
The subsequent upregulation of ACSL4 enhances the lipid peroxidation of polyunsaturated fatty acids, ultimately inducing ferroptosis ( Collectively, these mechanisms demonstrate that HIV proteins directly regulate core ferroptosis pathways, establishing a direct causal link from viral proteins to ferroptosis in host cells
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