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For some people, the bodys incretin response the hormone signal released from the gut after eating does not function properly

Thymosins in multiple sclerosis and its experimental models: Moving from basic to clinical application

GLP-1 receptors are very widely distributed, particularly in the brain, says Daniel Drucker, an endocrinologist at the University of Toronto, who has consulted for Novo Nordisk, Eli Lilly and other companies developing weight-loss drugs

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The first is to add a prandial insulin to the treatment regimen, either by adding a RAI prior to the largest meal of the day, with addition at other meals in stages if required (basal-plus), adding RAI at all meals (basal-bolus), or by switching to a premixed (biphasic) insulin formulation of intermediate- and short-acting insulins

Xu CT, Meng SY et al