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M., COUNCIL ON CHILDREN WITH DISABILITIES, SECTION ON DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, Kuo, D

Moreover, it is not known if S-5-HT mediated the effects of L-carnitine on fatigue, as it is possible that L-carnitine could have effects unrelated to S-5-HT that could reduce fatigue and in parallel promote increased synthesis of peripheral 5-HT

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Even if substrate-specificity is different in the rats small intestine, another factor challenges the hypothesis as PAT1 is dependent on the Na + /H + exchanger (NHE3) to create an H + -gradient for the transport