For most people taking B12 at standard supplemental doses as part of a well-formulated multivitamin, this isn't a concern
The CR process regulates the immune and physiological function, and any disruption in it leads to severe diseases, including cardiovascular, neurodegenerative, cancer, etc
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It also interacts with the F-actin cytoskeleton in fibroblasts, improving cell spreading and migration needed for wound closure
Oncogene 29 (34), 47524765