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Current evidence from randomised controlled trials, meta-analyses, and real-world studies indicates no consistent or causal relationship between these agents and serious GI side effects
Why it matters: REDEFINE 3 will be key for regulatory and clinical adoption of CagriSema
Participants were divided into three groups: one group (Group A) received tirzepatide starting at 2.5 mg per week and increased to 5 mg from the second month
Additionally, tirzepatide administration over an extended period raised BAT levels of several amino acids that have been demonstrated to be elevated in response to cold exposure
As shown in the pre-treatment AUC data ( Figure S4A , C , Method S3 ), all groups demonstrated elevated blood glucose excursions, consistent with impaired glucose tolerance
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