Poor nutritional status is often associated with chronic alcoholism, and thus alcoholic patients with APAP-induced hepatotoxicity may fall victim to both decreased body GSH stores as well as enhancement of the CYP enzymatic activity
*Correspondence: Baptist Gallwitz, [email protected] This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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Given the reduced levels of activated HGF and cMet in hepsin / mice, combined with the increased abundance of GJs, we hypothesize that these mice may be more vulnerable to oxidative stress, potentially exacerbating the severity of APAP-induced liver injury