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NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994

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This article is part of the PlexusDx Education Hub, our resource for evidence-based guidance on longevity protocols, peptide therapies, and the genetics behind metabolic decisions

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