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Redox signaling, alkylation (carbonylation) of conserved cysteines inactivates class I histone deacetylases 1, 2, and 3 and antagonizes their transcriptional repressor function

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Notably, other banned substances from the S4.1 group, such as aminoglutethimide, arimistane, formestane, or testolactone, may also be present in illegal samples purchased by athletes

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*Correspondence: Chao Liang, [email protected] These authors have contributed equally to this work This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers