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Besides its popularity for weight loss, berberine is also being studied for its effect on diabetes and heart disease risk factors

Am J Clin Nutr 93: 799-808

Repeated, method-validated measurements (scintigraphy or C-breath testing) in the same participants at treatment start and after weeks of steady state, for cagrilintide monotherapy, to test the tachyphylaxis hypothesis directly

I think sometimes if we can keep that in mind and know thats a possibility, then it can help us endure in the meantime.