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They have been widely used for NADs delivery due to their excellent compatibility with cell membranes

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A balance between free radicals and antioxidants is necessary for proper physiological function

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In LOsG-induced prediabetes, although pancreatic ROS stress remained high on LOsG treatment day 38, there were no alterations in mRNA levels of ER stress (XBP1 and BIP), inflammation (IL6 and IL1), and hypoxia-responsive (HIF1 and GAPDH) genes between LOsG- and sham-treated groups

However, this result is expected considering the very high activity of glutaredoxins as deglutathionylating enzymes and a decreased GSSR concentration neither excludes mechanism (ii) or (iii) from Fig