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If the headaches are part of the body adjusting to the medication, they may persist intermittently for the first couple weeks, particularly after dose increases. In general, though, most headaches are temporary and tend to resolve within a few hours to a couple of days, he adds

When the intracellular zinc concentration increases, zinc ions bind to MTF-1, causing a conformational change that enables MTF-1 to translocate to the nucleus and bind to MREs

This includes tendons, ligaments, muscles, bones, and joints