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CAP- or low pH-induced currents were recorded at a holding potential of 60 mV
Pattern 1: The Responder (approximately 60% of switchers) Achieves similar or better weight-loss velocity on Zepbound 7.5 to 10 mg compared to prior Wegovy 2.4 mg Tolerates titration well with transient nausea that resolves within 2 weeks per dose escalation Reaches maintenance dose by week 12 to 16 Reports subjective improvement in appetite suppression ("Zepbound feels stronger") This is the modal response
It has a short circulating half-life of approximately seven minutes due to rapid degradation by dipeptidyl peptidase IV (DPP-IV) ( Importantly, GLP-2R is not expressed on enterocytes
A., & Williams, B
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Maintenance doses usually range between 5 mg and 15 mg weekly depending on treatment response
