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The present review ultimately weighs early concerns against increasingly consistent evidence that GLP-1 RA use does not raise overall cancer risk, clarifies that breast cancer risk appears neutral, and further highlights key mechanisms, such as the reduction of hyperinsulinemia and immune-microenvironment modulation, through which these drugs may improve rather than exacerbate malignancy outcomes
Patients must maintain adequate fluid intake throughout treatment, which can be challenging when appetite and thirst signals are suppressed by medication
Although GIPR agonists do not require GLP-1R to decrease body weight (179, 184), GIPR agonism was recently shown to attenuate the emetic effects of GLP-1R agonism in mice, rats and musk shrews (188)
If youre considering trying a compounded GLP-1 drug for weight loss, or want to continue taking one, heres what to discuss with your doctor
The Medical clinics of North America, 102(1), 183197
Huang, and S.C
