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These salt forms of GLP-1s have not been proven safe and effective in humans or approved by the FDA, Basina noted, adding that effectiveness can be different due to the salt form differences. Additives To differentiate their products from the FDA-approved GLP-1s, many compounders add extra ingredients most commonly vitamin B12, but also B6, niacinamide, glycine or carnitine that have no proven benefit for weight loss or diabetes management
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They work through several important mechanisms: They increase insulin release from the pancreas when blood glucose is high They reduce excess glucose release from the liver They slow stomach emptying, helping prevent sharp glucose spikes after meals They increase feelings of fullness, often reducing appetite Because these effects depend on blood glucose levels, GLP-1 medications on their own carry a very low risk of causing low blood sugar (hypoglycaemia)
World Journal of Diabetes, 11 (2), 2632
The goal is safe, sustainable weight loss with manageable side effects
