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Some providers extend this to 5-6 weeks if you experience significant nausea or gastrointestinal side effects, allowing gradual GLP-1 receptor adaptation

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According to the manufacturer, Novo Nordisk, Wegovy can cause unpleasant gastrointestinal side effects, like nausea, vomiting, diarrhea, and stomach pain, and may result in hypoglycemia (low blood sugar) when combined with other medications that lower blood sugar, like insulin

Developer: Eli Lilly and Company Classification: Triple Agonist (GIP/GLP-1/Glucagon receptors) Administration: Once-weekly subcutaneous injection Development Status: Phase 3 clinical trials Expected FDA Approval: Q3 2026 to Q1 2027 Developer: Boehringer Ingelheim Classification: Dual Agonist (Glucagon/GLP-1 receptors) Administration: Once-weekly subcutaneous injection Development Status: Phase 3 clinical trials (SYNCHRONIZE program) Regulatory Status: FDA Breakthrough Therapy designation for MASH Retatrutide emerged from Eli Lillys research into multi-receptor agonism