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The authors found no significant differences in the efficacy analyses, though they reported the drug was well tolerated over the 7-day intravenous course in this small inpatient population a tolerability observation, not a safety profile [11]

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It is also worth noting that the delivery method matters

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That means current switching protocols come from trial designs and the expected behavior based on retatrutides pharmacology: 6-day half-life, triple receptor activity (GLP-1 plus GIP plus glucagon), and stepwise titration from 2 mg to 12 mg

Two cohorts were constructed using the criteria listed