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They reduce pathological drug and alcohol craving by normalizing dysregulated reward circuitry rather than suppressing it globally

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Seeley: GLP-1s are a safe and effective way to lose weight and treat diabetes

Williams ME, Howard D, Donnelly C, Izadi F, Parra JG, Pugh M, et al

FDA-approved for type 2 diabetes as Mounjaro (2022) and for chronic weight management as Zepbound (2023)

Ongoing research and investigational therapies, such as GIP/GLP-1/glucagon triple agonists, may inform future strategies for sustainable weight loss after discontinuation of weight loss pharmacotherapy