From an experimental design perspective, the key hypothesis is not that the peptides duplicate each others effects, but rather that they might support different rate-limiting steps in repair, such as cell recruitment to the injury site, fibroblast function, extracellular matrix organization, angiogenesis, and the transition from inflammatory signaling to remodeling
Importantly, this regulation cascade can be exploited by targeting YBX1 to block AMPK protein synthesis and targeting GLUT1 to induce energy stress, which synergistically blunts tumor growth in vivo
Presented for research literature review only Yoshida Y (2005)
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Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy [14]