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[3] If the acidosis improves following N-acetylcysteine, this supports the diagnosis of pyroglutamic acidosis

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Therefore, a variety of experimental studies and calculations consistently suggest a short half life in the 23 hour range

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Specifically, berberine can cause: Nausea Diarrhea Stomach cramps Bloating Headache Constipation (particularly when you stop taking it) Rashes (though this is relatively rare) The more berberine you take, the more likely you are to experience these side effects

Fang X, Ardehali H, Min J, Wang F