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There is a growing interest in using GLP-1RAs as a therapeutic agent for the treatment of motivation and reward-related behavioral disorders
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The pre-sleep dose aligns with natural GH secretion patterns, while the fasted morning dose takes advantage of low insulin levels, which can enhance GH release
DumayEChevalier-LuciaDPicart-PalmadeLBenzariaAGrcia-JuliABlayoC
Here, the method was applied in a systematic fashion to the 31 amino acid peptide GLP-1 to generate a series of GLP-1-oligourea hybrids among which potent agonists of GLP-1R were identified
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