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Heart rate changes represent one of the most frequently reported side effects among patients starting GLP-1 therapy, with clinical trials documenting increases ranging from 2 to 8 beats per minute in certain populations

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Key takeaways Semaglutide, liraglutide, dulaglutide, and tirzepatide are GLP-1 medications that mimic hormones to control blood sugar and reduce weight

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The IC 50 values for the calcium response of GLP-1, liraglutide, exendin-4, and exendin 939 were 178.60, 62.19, 64.49, and 28.18 nM, respectively (Fig