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GHK-Cu is a photolabile copper(II) complex, and freeze-thaw cycling can disrupt the copper coordination sphere independently of any damage to the peptide backbone
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These effects are context-dependent and vary with concentration, exposure duration, and experimental system, making GHK-Cu a widely used molecular tool for investigating copper-mediated signalling and peptidemetal interactions in vitro and in vivo
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miR-92a regulates Theca cell androgen production by targeting GATA6 and IRS2
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