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Ozempic and Wegovy is set to be challenged by cut-price generic semaglutide following Indias patent expiry, potentially expanding access while raising safety and oversight concerns

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Specifically, semaglutide (2.4 mg) improved obesity-related HF symptoms in people with inflammation and both with and without atrial fibrillation (AFib), plus improved cardiac structure and function

For example, gut microbiota-derived indole-3-acetic acid (3-IAA), a tryptophan metabolite, accumulates in the TME and is oxidized by neutrophil myeloperoxidase (MPO), generating a burst of ROS

Interested in finding a way to offset glucagon's effect in raising blood sugar, the two researchers wondered if it was possible to create a dual agonist drug that targeted both GLP-1 and glucagon receptors