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Like its injectable counterpart, it also carries approval to reduce the risk of major adverse cardiovascular events (MACE), including cardiovascular death, heart attack, and stroke, in adults with established heart disease and obesity or overweight

These side effects often lessen over time

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Although initial findings suggest that GLP-1Ra leads to a slight reduction in bone mineral density and promotes bone remodeling, favoring resorption similar to calorie restriction effects, further research is needed to explore the effects of GLP-1Ra on bone metabolism and fracture-related outcomes, as well as dual- and triple-receptor agonists of GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon in PwO