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However, retatrutide is earlier in clinical development and not yet available

After washing, 50 L/well of HRP-conjugated detection antibody anti-Ig-HRP (Cytiva NA9310-1ML) was added for 1 h at RT

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In patients with first recurrence of glioblastoma, PT2385 was evaluated in a Phase II single-arm clinical trial (NCT03216499), where the median progression-free survival (PFS) was 1.8 months and the median overall survival (OS) was 7.7 months

For GOF mutations, developing targeted therapies that specifically inhibit the oncogenic functions of GOF mutant p53 may help suppress the survival and progression of tumors