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This suggests that the observed activation in many brain regions is indirect likely triggered by the drug binding in more accessible areas, such as the circumventricular organs, which then transmit signals to other parts of the brain

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Policy changes like the Inflation Reduction Acts $2,000 out-of-pocket (OOP) cap for Medicare Part D beneficiaries may offer some relief, as patients who reach the cap pay $0 thereafter, but they also risk prompting payers to tighten coverage for high-cost drugs, especially those indicated for obesity

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