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Preclinical studies in rodents have demonstrated reductions in fat mass, improved insulin sensitivity, and increased metabolic rate without significant changes to food intake (Neelakantan et al., 2019)

BAIBA has been shown to activate AMPK as well as the transcription factors of the peroxisome proliferator-activated receptor family, PPAR and PPAR/, while simultaneously inhibiting PPAR

Translation to human clinical application has been narrower than the breadth of the preclinical literature would suggest

In the most severe cases patients have elevated serum levels of C10:2-carnitine

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