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The phenomenon of ligand-directed signalling bias for GLP-1R has recently been described using the endpoints of cAMP production, pERK1/2 and intracellular Ca 2+

Although the adapted program is the optimal solution under current conditions, if the intracellular stress signal persists and the ER function cannot return to normal, the apoptotic program might be initiated (291)

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De Fano et al.)

Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

Lancet 2004